SLC51B Antibody, FITC conjugated

Datasheet

Code	CSB-PA771440LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SLC51B Polyclonal antibody

Uniprot No.

Q86UW2

Target Names

SLC51B

Alternative Names

SLC51B antibody; OSTB antibody; Organic solute transporter subunit beta antibody; OST-beta antibody; Solute carrier family 51 subunit beta antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Organic solute transporter subunit beta protein (57-128AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities.

Gene References into Functions

Dileucine motif in the extracellular N-terminal region is essential for OSTB plasma membrane targeting. PMID: 27351185
Hepatic OSTalpha-OSTbeta expression is induced by hypoxia. PMID: 24703425
OSTbeta is a target of RARalpha-mediated (by binding to DR5 response element) gene regulation pathways PMID: 24264050
Ostbeta is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta critical for these processes. PMID: 22535958
The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta in different tissues. PMID: 21691099
OSTbeta is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS homeostasis PMID: 20649839
OSTbeta has roles in biological transport and is widely expressed in human tissues PMID: 12719432
overexpression of human OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate and the activation of FXR target genes PMID: 16251721
OSTalpha/OSTbeta expression is induced by bile acids through ligand-dependent transactivation of both OST genes by the nuclear bile acid receptor/farnesoid X receptor (FXR). PMID: 16269519
the selective localization of OSTalpha and OSTbeta to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption. PMID: 16317684
These results indicate that expression of Ostalpha and Ostbeta are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor. PMID: 16423920
Demonstrate association of OST-alpha and OST-beta to determine trafficking to plasma membrane and activity. PMID: 17332473
The mRNA expression of OSTalpha-OSTbeta was significantly reduced (OSTalpha: 3.3-fold, P = 0.006; OSTbeta: 2.6-fold, P = 0.03) in normal-weight but not overweight gallstone carriers PMID: 18469300
interaction of solute transporter beta with human organic solute transporter alpha. PMID: 18847488

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Subcellular Location

Cell membrane; Single-pass membrane protein. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.

Protein Families

OST-beta family

Tissue Specificity

Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat.

Database Links

HGNC: 29956

OMIM: 612085

KEGG: hsa:123264

STRING: 9606.ENSP00000335292

UniGene: Hs.27018

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